PR Newswire
02 Aug 2022, 06:37 GMT+10
DAEJEON, South Korea, Aug. 2, 2022 /PRNewswire/ -- GenKOre, a biotech start-up in Korea, succeeded in the development of ABEs based on its own hypercompact gene-editing technology and had the relevant study published on Nature Chemical Biology on August 2, 2022.
GenKOre (homepage: www.genkore.com) is a business spun off from the Korea Research Institute of Bioscience and Biotechnology (KRIBB), which is a government-invested research institute in Korea. It has platform business through proprietary gene-editing platform. GenKOre succeeded in the development of a hypercompact CRISPR system with AAV delivery compatibility termed TaRGET (Tiny nuclease/augment RNA-based Genome Editing Technology), which was published on Nature Biotechnology in 2021. The AAV-loadable ABE technology was derived from the TaRGET platform.
The hypercompact ABEs developed by GenKOre is characterized by compactness in size that can be delivered using AAV and boast of specific and versatile base-editing activity, which was also validated in vivo. Previous base-editing technology was developed based on such a 'big' SpCas9 nuclease that it cannot be delivered by payload-limiting AAV vectors and has been thus confined for hepatic delivery. This new base-editing technology is expected to provide various in vivo treatment options for genetic diseases through AAV delivery.
GenKOre recently expanded its research facility in Seoul in an effort to attract a large number of human resources for the development of hypercompact ABEs-based gene therapy, seeking collaborations with pharmaceutical companies and academia. Besides, it is expanding business to ex vivo gene therapy by making strategic alliance with companies with expertise in immune cells and hematopoietic stem cells. The ABE platform will be thus employed to develop ex vivo gene-editing therapy.
Details of said content published on Nature Chemical Biology can be checked at: https://www.nature.com/articles/s41589-022-01077-5.
GenKOre website: www.genkore.com
SOURCE GenKOre
Get a daily dose of Singapore Star news through our daily email, its complimentary and keeps you fully up to date with world and business news as well.
Publish news of your business, community or sports group, personnel appointments, major event and more by submitting a news release to Singapore Star.
More InformationWEST JERUSALEM, Israel - The Israel Air Force has launched a pre-emptive Pearl Harbour style air raid over Iran, dropping bombs over...
NEW DELHI, India - The world is in shock following Thursday's devastating plane crash in India which has killed at least 290 people,...
WASHINGTON, D.C.: The United States has placed sanctions on two sons of jailed Mexican drug lord Joaquin El Chapo Guzman. These two...
LONDON, UK: Frederick Forsyth, the renowned British author behind The Day of the Jackal and numerous other bestselling thrillers, has...
PUERTO PRINCESA, Philippines: A Chinese ship got stuck in shallow waters near a Philippine-controlled island in the disputed South...
Nearly three months after a devastating earthquake struck Myanmar, the country remains trapped in a deepening crisis, compounded by...
SAN FRANCISCO, California: In a move that highlights how the demand for compute power is reshaping the AI industry, OpenAI has signed...
BEIJING/SHANGHAI, China: What started as a surprise toy from a blind box has now entered the elite world of high-value collectibles....
NEW YORK, New York - U.S. stocks rose modestly on Thursday while the U.S. dollar sank to its lowest level in 3 years after President...
HARRISBURG, Pennsylvania: Amazon is making a significant play in Pennsylvania, announcing plans to pour at least US$20 billion into...
MUMBAI/LONDON: Fast-fashion giant Shein and India's Reliance Retail are preparing to transform India into a significant global supply...
BURBANK, California: Warner Bros Discovery is officially breaking itself in two. In a move that signals a major pivot for the media...